Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus.
Maximillian S Habibi, Agnieszka Jozwik, Spyridon Makris, Jake Dunning, Allan Paras, John P DeVincenzo, Cornelis AM de Haan, Jens Wrammert, Peter JM Openshaw, Christopher Chiu, undefined Mechanisms of Severe Acute Influenza Consortium Investigators
Am J Respir Crit Care Med | Published : 2015
RATIONALE: Despite relative antigenic stability, respiratory syncytial virus (RSV) reinfects throughout life. After more than 40 years of research, no effective human vaccine exists and correlates of protection remain poorly defined. Most current vaccine candidates seek to induce high levels of RSV-specific serum neutralizing antibodies, which are associated with reduced RSV-related hospitalization rates in observational studies but may not actually prevent infection. OBJECTIVES: To characterize correlates of protection from infection and the generation of RSV-specific humoral memory to promote effective vaccine development. METHODS: We inoculated 61 healthy adults with live RSV and studied ..View full abstract
Awarded by Wellcome Trust
Awarded by Medical Research Council