Journal article

B cell responses to influenza infection and vaccination.

Christopher Chiu, Ali H Ellebedy, Jens Wrammert, Rafi Ahmed

Curr Top Microbiol Immunol | Published : 2015


Although vaccines against influenza are widely available, control of the disease remains elusive. In part, this is due to the inability of current vaccines to induce durable, broadly protective immune responses. Prevention of influenza depends primarily on effective antibody responses that block virus entry. Following infection, high-affinity IgA antibodies are generated in the respiratory tract that lead to immune exclusion, while IgG prevents systemic spread. These are effective and long-lasting but also exert immune pressure. Mutation of the antigenic determinants of influenza therefore rapidly leads to emergence of novel variants that evade previously generated protective responses. Not ..

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University of Melbourne Researchers


Awarded by Medical Research Council

Awarded by NIH HHS

Awarded by NIAID NIH HHS