Journal article

Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans.

Ali H Ellebedy, Florian Krammer, Gui-Mei Li, Matthew S Miller, Christopher Chiu, Jens Wrammert, Cathy Y Chang, Carl W Davis, Megan McCausland, Rivka Elbein, Srilatha Edupuganti, Paul Spearman, Sarah F Andrews, Patrick C Wilson, Adolfo García-Sastre, Mark J Mulligan, Aneesh K Mehta, Peter Palese, Rafi Ahmed

Proc Natl Acad Sci U S A | Published : 2014


The emergence of pandemic influenza viruses poses a major public health threat. Therefore, there is a need for a vaccine that can induce broadly cross-reactive antibodies that protect against seasonal as well as pandemic influenza strains. Human broadly neutralizing antibodies directed against highly conserved epitopes in the stem region of influenza virus HA have been recently characterized. However, it remains unknown what the baseline levels are of antibodies and memory B cells that are directed against these conserved epitopes. More importantly, it is also not known to what extent anti-HA stem B-cell responses get boosted in humans after seasonal influenza vaccination. In this study, we ..

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University of Melbourne Researchers