Journal article

Current concepts and progress in RSV vaccine development.

Aleks K Guvenel, Christopher Chiu, Peter Jm Openshaw

Expert Rev Vaccines | Published : 2014

Abstract

Respiratory syncytial virus (RSV) disease is an important cause of morbidity and mortality in children and debilitated adults and remains one of the major global unmet challenges for vaccine development. Several immunological issues have delayed the development of vaccines, especially the poorly protective response to natural infection and the enhancement of disease following administration of formalin inactivated vaccines during trials conducted in the 1960s. Advances in knowledge of the immune system, of the virus and its antigenic properties combined with new vaccine technologies are now injecting new hope into the field and have given rise to many promising vaccine approaches. Some of th..

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University of Melbourne Researchers