Renal nerves contribute to hypertension in Schlager BPH/2J mice

C Gueguen; KL Jackson; FZ Marques; N Eikelis; S Phillips; ER Stevenson; FJ Charchar; GW Lambert; PJ Davern; GA Head

Journal article

Renal nerves contribute to hypertension in Schlager BPH/2J mice

C Gueguen, KL Jackson, FZ Marques, N Eikelis, S Phillips, ER Stevenson, FJ Charchar, GW Lambert, PJ Davern, GA Head

Hypertension Research | NATURE PUBLISHING GROUP | Published : 2019

DOI: 10.1038/s41440-018-0147-9

Abstract

Schlager mice (BPH/2J) are hypertensive due to a greater contribution of the sympathetic nervous system (SNS) and renin-angiotensin system (RAS). The kidneys of BPH/2J are hyper-innervated suggesting renal nerves may contribute to the hypertension. We therefore determined the effect of bilateral renal denervation (RD) on hypertension in BPH/2J. Mean arterial pressure (MAP) was measured by radiotelemetry before and for 3 weeks after RD in BPH/2J and BPN/3J. The effects of pentolinium and enalaprilat were examined to determine the contribution of the SNS and RAS, respectively. After 3 weeks, MAP was −10.9 ± 2.1 mmHg lower in RD BPH/2J compared to baseline and −2.1 ± 2.2 mmHg in sham BPH/2J (P ..

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University of Melbourne Researchers

MR Fadi Charchar Author

Grants

Awarded by State Government of Victoria

Funding Acknowledgements

This work was supported by grants from the National Health & Medical Research Council of Australia (NHMRC, Project grant 1065714) and in part by the Victorian Government's OIS Program. Investigators were supported by NHMRC/NHF Postdoctoral Fellowships (APP1012881 to P.J.D. NHMRC APP1052659 and National Heart Foundation PF12M6785/101185 co-shared to F.Z.M., NHMRC APP1091688 to K.L.J.) and NHMRC Research Fellowships to G.W.L.: APP1042492 and G.A.H.: APP1002186).