Journal article

The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies

Eleanor L Watts, Aurora Perez-Cornago, Paul N Appleby, Demetrius Albanes, Eva Ardanaz, Amanda Black, H Bas Bueno-de-Mesquita, June M Chan, Chu Chen, SA Paul Chubb, Michael B Cook, Melanie Deschasaux, Jenny L Donovan, Dallas R English, Leon Flicker, Neal D Freedman, Pilar Galan, Graham G Giles, Edward L Giovannucci, Marc J Gunter Show all

International Journal of Cancer | WILEY | Published : 2019

Abstract

Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric m..

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