Journal article

Pulmonary Mycobacterium abscessus complex in children with cystic fibrosis: A practical management guideline

Eden C Andrew, Tom Connell, Phil Robinson, Nigel Curtis, John Massie, Colin Robertson, Joanne Harrison, Shivanthan Shanthikumar, Penelope A Bryant, Mike Starr, Andrew Steer, Sarath Ranganathan, Amanda Gwee

JOURNAL OF PAEDIATRICS AND CHILD HEALTH | WILEY | Published : 2019

Abstract

The treatment of Mycobacterium abscessus complex (MABSC) pulmonary infections is an emerging challenge in patients with cystic fibrosis (CF). Multidrug therapy for prolonged durations is required and carries the significant burden of drug-related toxicity, cost and selective pressure for multiresistant bacteria. International guidelines acknowledge that clinical and in vitro data to support treatment regimens are limited, particularly in children. As part of a collaboration between the infectious diseases and respiratory units at our institution, we have developed a modified treatment guideline that aims to balance the aims of MABSC eradication and slowing disease progression with minimising..

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