Incidence, Clearance, and Persistence of Anal Human Papillomavirus in Men Who Have Sex With Men Living With Human Immunodeficiency Virus: Implications for Human Papillomavirus Vaccination.
Jason J Ong, Sandra Walker, Andrew Grulich, Jennifer Hoy, Tim RH Read, Catriona Bradshaw, Marcus Chen, Suzanne M Garland, Alyssa Cornall, Richard Hillman, David J Templeton, Jane Hocking, Beng Eu, BK Tee, Eric PF Chow, Christopher K Fairley
Sex Transm Dis | Published : 2019
BACKGROUND: Men who have sex with men living with human immunodeficiency virus have a high risk of anal cancer. We estimate the likely benefit of human papillomavirus (HPV) vaccination among participants of the Anal Cancer Examination study. METHODS: Anal swabs were collected for the detection and genotyping of anal HPV DNA by linear array (Roche Diagnostics) in this 2-year multicenter prospective cohort. We calculated the proportion of men, stratified by age, without detectable vaccine type-specific DNA. RESULTS: Overall, 255 men, with a median age of 50 years (interquartile range, 44-56 years) contributed 488.9 person-years of follow-up. After 2 years of follow-up, 149 (58%; 95% confidence..View full abstract