Journal article

Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland

Aleix Arnau-Soler, Erin Macdonald-Dunlop, Mark J Adams, Toni-Kim Clarke, Donald J MacIntyre, Keith Milburn, Lauren Navrady, Caroline Hayward, Andrew M McIntosh, Pippa A Thomson, Naomi R Wray, Stephan Ripke, Manuel Mattheisen, Maciej Trzaskowski, Enda M Byrne, Abdel Abdellaoui, Esben Agerbo, Tracy M Air, Till FM Andlauer, Silviu-Alin Bacanu Show all

TRANSLATIONAL PSYCHIATRY | NATURE PUBLISHING GROUP | Published : 2019

Abstract

Stress is associated with poorer physical and mental health. To improve our understanding of this link, we performed genome-wide association studies (GWAS) of depressive symptoms and genome-wide by environment interaction studies (GWEIS) of depressive symptoms and stressful life events (SLE) in two UK population-based cohorts (Generation Scotland and UK Biobank). No SNP was individually significant in either GWAS, but gene-based tests identified six genes associated with depressive symptoms in UK Biobank (DCC, ACSS3, DRD2, STAG1, FOXP2 and KYNU; p < 2.77 × 10-6). Two SNPs with genome-wide significant GxE effects were identified by GWEIS in Generation Scotland: rs12789145 (53-kb downstream PI..

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University of Melbourne Researchers