Mice overexpressing hepcidin suggest ferroportin does not play a major role in Mn homeostasis
Lian Jin, David M Frazer, Yan Lu, Sarah J Wilkins, Scott Ayton, Ashley Bush, Gregory J Anderson
METALLOMICS | ROYAL SOC CHEMISTRY | Published : 2019
Manganese is an essential metal that is required for a wide range of biological functions. Ferroportin (FPN), the only known cellular exporter of iron, has also been proposed to play a role in manganese export, but this relationship is incompletely understood. To investigate this in more detail in vivo, we examined the relative distributions of manganese and iron in TMPRSS6 deficient mice, which are characterized by constitutively high expression of the iron regulatory hormone hepcidin and, consequently, very low FPN levels in their tissues. Tmprss6-/- mice showed frank iron deficiency and reduced iron levels in most tissues, consistent with FPN playing an important role in the distribution ..View full abstract
Awarded by National Health and Medical Research Council of Australia (NHMRC)
This work was supported by Project Grant APP1051882 from the National Health and Medical Research Council of Australia (NHMRC). LJ was supported by a University of Queensland International Scholarship and GJA was supported by a Senior Research Fellowship from the NHMRC.