Inter- and Intra-Hemispheric Fibers of Olfactory and Motor Areas in Kallmann Syndrome with Defective Corpus Callosum

Abstract

Kallmann syndrome (KS) is a form of hypogonadotropic hypogonadism with variable disturbances of olfaction, with some patients having complete anosmia. In this study, we report observations of cerebral white matter connectivity in a rare patient diagnosed with KS associated with a defective corpus callosum (DCC) (KS-DCC) using non-invasive tractography-based diffusion tensor imaging (DTI). In the partial CC, two genua remnants were observed. The KS-DCC patient had a normal life without cognitive impairment and had a normal intelligence quotient, manifesting only the two common symptoms hypogonadotropic hypogonadism and anosmia. Mirror movements were not observed. Compared with normal, DTI tra..