Journal article

Deep brain stimulation in the lateral orbitofrontal cortex impairs spatial reversal learning

Marianne Klanker, Ger Post, Ruud Joosten, Matthijs Feenstra, Damiaan Denys

BEHAVIOURAL BRAIN RESEARCH | ELSEVIER | Published : 2013

Abstract

Deep Brain Stimulation (DBS) is a successful novel treatment for treatment-resistant obsessive-compulsive disorder and is currently under investigation for addiction and eating disorders. Clinical and preclinical studies have shown functional changes in the orbitofrontal cortex (OFC) following DBS in the ventral capsule/ventral striatum. These findings suggest that DBS can affect neural activity in distant regions that are connected to the site of electrode implantation. However, the behavioral consequences of direct OFC stimulation are not known. Here, we studied the effects of direct stimulation in the lateral OFC on spatial discrimination and reversal learning in rats. Rats were implanted..

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University of Melbourne Researchers