Journal article

Unaltered Instrumental Learning and Attenuated Body-Weight Gain in Rats During Non-rotating Simulated Shiftwork

CHC Leenaars, A Kalsbeek, MAJ Hanegraaf, E Foppen, RNJMA Joosten, G Post, M Dematteis, MGP Feenstra, EJW van Someren

CHRONOBIOLOGY INTERNATIONAL | TAYLOR & FRANCIS INC | Published : 2012

Abstract

Exposure to shiftwork has been associated with multiple health disorders and cognitive impairments in humans. We tested if we could replicate metabolic and cognitive consequences of shiftwork, as reported in humans, in a rat model comparable to 5 wks of non-rotating night shifts. The following hypotheses were addressed: (i) shiftwork enhances body-weight gain, which would indicate metabolic effects; and (ii) shiftwork negatively affects learning of a simple goal-directed behavior, i.e., the association of lever pressing with food reward (instrumental learning), which would indicate cognitive effects. We used a novel method of forced locomotion to model work during the animals' normal resting..

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University of Melbourne Researchers