Unaltered Instrumental Learning and Attenuated Body-Weight Gain in Rats During Non-rotating Simulated Shiftwork
CHC Leenaars, A Kalsbeek, MAJ Hanegraaf, E Foppen, RNJMA Joosten, G Post, M Dematteis, MGP Feenstra, EJW van Someren
CHRONOBIOLOGY INTERNATIONAL | TAYLOR & FRANCIS INC | Published : 2012
Exposure to shiftwork has been associated with multiple health disorders and cognitive impairments in humans. We tested if we could replicate metabolic and cognitive consequences of shiftwork, as reported in humans, in a rat model comparable to 5 wks of non-rotating night shifts. The following hypotheses were addressed: (i) shiftwork enhances body-weight gain, which would indicate metabolic effects; and (ii) shiftwork negatively affects learning of a simple goal-directed behavior, i.e., the association of lever pressing with food reward (instrumental learning), which would indicate cognitive effects. We used a novel method of forced locomotion to model work during the animals' normal resting..View full abstract
Awarded by Netherlands Organization for Scientific Research, The Hague, The Netherlands
This work was supported by the Netherlands Organization for Scientific Research, The Hague, The Netherlands (Cognition-Integrated Research Projects 051-04-010 and VICI 453-07-001).