Journal article

Mitochondrial Complex II: At the Crossroads

Ayenachew Bezawork-Geleta, Jakub Rohlena, Lanfeng Dong, Karel Pacak, Jiri Neuzil

TRENDS IN BIOCHEMICAL SCIENCES | ELSEVIER SCIENCE LONDON | Published : 2017

Abstract

Mitochondrial complex II (CII), also called succinate dehydrogenase (SDH), is a central purveyor of the reprogramming of metabolic and respiratory adaptation in response to various intrinsic and extrinsic stimuli and abnormalities. In this review we discuss recent findings regarding SDH biogenesis, which requires four known assembly factors, and modulation of its enzymatic activity by acetylation, succinylation, phosphorylation, and proteolysis. We further focus on the emerging role of both genetic and epigenetic aberrations leading to SDH dysfunction associated with various clinical manifestations. This review also covers the recent discovery of the role of SDH in inflammation-linked pathol..

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Grants

Awarded by Czech Science Foundation


Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT


Funding Acknowledgements

This work was supported in part by grants from the Australian Research Council and the Czech Science Foundation (15-02203S, 16-12719S) to J.N. and the Czech Science Foundation (17-20904S) to J.R.