Mitochondrial complex II, a novel target for anti-cancer agents
Katarina Kluckova, Ayanachew Bezawork-Geleta, Jakub Rohlena, Lanfeng Dong, Jiri Neuzil
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | ELSEVIER SCIENCE BV | Published : 2013
With the arrival of the third millennium, in spite of unprecedented progress in molecular medicine, cancer remains as untamed as ever. The complexity of tumours, dictating the potential response of cancer cells to anti-cancer agents, has been recently highlighted in a landmark paper by Weinberg and Hanahan on hallmarks of cancer . Together with the recently published papers on the complexity of tumours in patients and even within the same tumour (see below), the cure for this pathology seems to be an elusive goal. Indisputably, the strategy ought to be changed, searching for targets that are generally invariant across the landscape of neoplastic diseases. One such target appears to be the..View full abstract
Awarded by Czech Science Foundation
J.N. was supported in part by the Australian Research Council, National Health and Medical Research Council of Australia, Cancer Council Queensland, the Clem Jones Foundation and the Czech Science Foundation (P301/10/1937), L.F.D. by the Australian Research Council, K.K. and J.R by the Czech Science Foundation (P301/12/1851).