Conference Proceedings
Determining the pneumococcal conjugate vaccine coverage required for indirect protection within Asia and the Pacific: a prospective observational study
Jocelyn Chan, Jana Y Lai, Claire von Mollendorf, Christopher Blyth, David AB Dance, Siddhartha Datta, Eileen M Dunne, Rebecca Ford, Kimberley Fox, Jason Hinds, Keoudomphone Vilivong, Sophie La Vincente, Deborah Lehmann, Kerryn A Moore, Tuya Mungun, Monica L Nation, Paul N Newton, Cattram D Nguyen, William Pomat, Anonh Xeuatvongsa Show all
LANCET GLOBAL HEALTH | ELSEVIER SCI LTD | Published : 2019
Open access
Abstract
Background Pneumococcal disease is an important cause of childhood morbidity and mortality worldwide. Evidence is required to support the introduction of pneumococcal conjugate vaccines (PCVs) in low-income and middle-income countries (LMICs). PCVs prevent disease through both direct protection of vaccinated individuals, and indirect protection of unvaccinated people via reduction of nasopharyngeal carriage and transmission of vaccine-type (VT) pneumococci. We aimed to determine the degree of this indirect effect after introduction of 13-valent PCV (PCV13) at three sites in Asia-Pacific, and describe the relationship between PCV coverage and indirect protection. Methods We are recruiting and..
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Funding Acknowledgements
Bill & Melinda Gates Foundation, Gavi the Vaccine Alliance.