Journal article
Increased carotid intima-media thickness in children with a history of dengue hemorrhagic fever
T Versteege, MR Karyanti, W Septiani, AL Widjanarko, NS Idris, A Hendarto, DE Grobbee, D Burgner, CSPM Uiterwaal, PCJL Bruijning-Verhagen
American Journal of Tropical Medicine and Hygiene | AMER SOC TROP MED & HYGIENE | Published : 2019
Abstract
We assessed carotid intima-media thickness (cIMT) and arterial stiffness in 28 children and adolescents with previous dengue hemorrhagic fever (DHF) (mean interval between DHF and cardiovascular assessment, 8.4 years), and 34 controls in a low-resource setting. Participants with previous DHF had an adjusted increased cIMT of 42.6 μm (95% confidence interval [CI]: 10.0–75.3, P = 0.01), and 61.7 μm (95% CI: 21.5–102.0, P < 0.01) in a subgroup analysis on dengue shock syndrome. There were no differences in arterial stiffness. In this first exploratory study, children and adolescents with a history of DHF had an increased cIMT, which may be modulated by dengue severity.