Journal article

Associations Between Telomere Length and Hearing Status in Mid-Childhood and Midlife: Population-Based Cross-Sectional study

Jing Wang, Thien Nguyen Minh, Valerie Sung, Anneke Grobler, David Burgner, Richard Saffery, Melissa Wake

Ear and Hearing | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019

Abstract

OBJECTIVES: The purpose of this study is to determine if telomere length (a biomarker of aging) is associated with hearing acuity in mid-childhood and midlife. DESIGN: The study was based on the population-based cross-sectional study within the Longitudinal Study of Australian Children with telomere length and audiometry data. We calculated high Fletcher Index (hFI, mean threshold of 1, 2, and 4 kHz), defining hearing loss as threshold >15 dB HL (better ear). Linear and logistic regression analyses quantified associations of telomere length with continuous hearing threshold and binary hearing loss outcomes, respectively. RESULTS: One thousand one hundred ninety-five children (mean age 11.4 y..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by Royal Children's Hospital Foundation


Awarded by National Heart Foundation of Australia


Awarded by Financial Markets Foundation for Children


Awarded by NHMRC


Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (NHMRC) Project Grants 1041352 and 1109355, The Royal Children's Hospital Foundation (2014-241), the Murdoch Children's Research Institute, The University of Melbourne, the National Heart Foundation of Australia (100660), Financial Markets Foundation for Children (2014-055, 2016-310), and the Victorian Deaf Education Institute. The funding bodies did not play any role in the study. J.W. was supported by the University of Melbourne Postgraduate Scholarship and the Murdoch Children's Research Institute PhD Top Up Scholarship. The following authors were supported by the NHMRC: M.T.N. (Postgraduate Scholarship 1115167), V.S. (Early Career Fellowship 1125687), D.B. (Senior Research Fellowship 1064629), R.S. (Senior Research Fellowship 1045161), and M.W. (Senior Research Fellowship 1046518) in this work. V.S. was additionally supported by a Cottrell Research Fellowship from the Royal Australasian College of Physicians, and M.W. by Cure Kids New Zealand. The MCRI administered the research grants for the study and provided infrastructural support (IT and biospecimen management) to its staff and the study but played no role in the conduct or analysis of the trial. The authors declare no potential conflicts of interest, including no specific financial interests relevant to the subject of this manuscript.