Journal article

Superassembled Biocatalytic Porous Framework Micromotors with Reversible and Sensitive pH-Speed Regulation at Ultralow Physiological H2O2 Concentration

Song Gao, Jingwei Hou, Jie Zeng, Joseph J Richardson, Zi Gu, Xiang Gao, Dongwei Li, Meng Gao, Da-Wei Wang, Pu Chen, Vicki Chen, Kang Liang, Dongyuan Zhao, Biao Kong

Advanced Functional Materials | WILEY-V C H VERLAG GMBH | Published : 2019

Abstract

Synthetic nano/micromotors are a burgeoning class of materials with vast promise for applications ranging from environmental remediation to nanomedicine. The motility of these motors is generally controlled by the concentration of accessible fuel, and therefore, engineering speed‐regulation mechanisms, particularly using biological triggers, remains a continuing challenge. Here, control over the movement of superassembled porous framework micromotors via a reversible, biological‐relevant pH‐responsive regulatory mechanism is demonstrated. Succinylated β‐lactoglobulin and catalase are superassembled in porous framework particles, where the β‐lactoglobulin is permeable at neutral pH. This perm..

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University of Melbourne Researchers

Grants

Awarded by National Key Research and Development Program of China


Awarded by Australia National Health and Medical Research Council (NHMRC) Career Development Fellowship


Awarded by Australian Research Council


Awarded by National Natural Science Foundation of China


Funding Acknowledgements

This work was supported by the National Key Research and Development Program of China (2017YFA0206901, 2017YFA0206900), the Australia National Health and Medical Research Council (NHMRC) Career Development Fellowship (APP1163786), the Scientia Fellowship program at UNSW, the Australian Research Council DP190101008, the MCTL Visiting Fellowship Program, the National Natural Science Foundation of China (21705027), the Natural Science Foundation of Shanghai, and the Recruitment Program of Global Experts of China and the Thousand Talent Plan of Shanghai. Part of the experiment was conducted at the small/wide angle X-ray scattering beamline at the Australian Synchrotron, part of ANSTO.