Cognitive domains that predict time to diagnosis in prodromal Huntington disease
Deborah Lynn Harrington, Megan M Smith, Ying Zhang, Noelle E Carlozzi, Jane S Paulsen
Journal of Neurology, Neurosurgery & Psychiatry | BMJ PUBLISHING GROUP | Published : 2012
BACKGROUND: Prodromal Huntington's disease (prHD) is associated with a myriad of cognitive changes but the domains that best predict time to clinical diagnosis have not been studied. This is a notable gap because some domains may be more sensitive to cognitive decline, which would inform clinical trials. OBJECTIVES: The present study sought to characterise cognitive domains underlying a large test battery and for the first time, evaluate their ability to predict time to diagnosis. METHODS: Participants included gene negative and gene positive prHD participants who were enrolled in the PREDICT-HD study. The CAG-age product (CAP) score was the measure of an individual's genetic signature. A fa..View full abstract
Awarded by National Institute of Neurological Disorders and Stroke
Awarded by Medical Research Council
This research is supported by the National Institutes for Health, National Institute of Neurological Disorders and Stroke (NS40068) and CHDI Foundation Inc.