Journal article

Role of gp130 in basal and exercise-trained skeletal muscle mitochondrial quality control

Dennis K Fix, Justin P Hardee, Song Gao, Brandon N VanderVeen, Kandy T Velazquez, James A Carson

JOURNAL OF APPLIED PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2018

Abstract

The IL-6 cytokine family activates intracellular signaling pathways through glycoprotein-130 (gp130), and this signaling has established regulatory roles in muscle glucose metabolism and proteostasis. Although the IL-6 family has been implicated as myokines regulating the muscles' metabolic response to exercise, gp130's role in mitochondrial quality control involving fission, fusion, mitophagy, and biogenesis is not well understood. Therefore, we examined gp130's role in basal and exercise-trained muscle mitochondrial quality control. Muscles from C57BL/6, skeletal muscle-specific gp130 knockout (KO) mice, and C2C12 myotubes, were examined. KO did not alter treadmill run-to-fatigue or indice..

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University of Melbourne Researchers

Grants

Awarded by National Cancer Institute


Awarded by National Center for Research Resources


Awarded by NATIONAL CANCER INSTITUTE


Awarded by National Center for Complementary & Integrative Health


Funding Acknowledgements

This work was supported by National Cancer Institute Grants R01-CA-121249 (J. A. Carson) and 07S1-CA-121249 (K. T. Velazquez) and National Center for Research Resources Grant P20-RR-017698.