Journal article

Coagulotoxic effects by brown snake (Pseudonaja) and taipan (Oxyuranus) venoms, and the efficacy of a new antivenom

Christina N Zdenek, Chris Hay, Kevin Arbuckle, Timothy NW Jackson, Mettine HA Bos, Bianca op den Brouw, Jordan Debono, Luke Allen, Nathan Dunstan, Terry Morley, Maria Herrera, Jose M Gutierrez, David J Williams, Bryan G Fry

TOXICOLOGY IN VITRO | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019

Abstract

Snakebite is a neglected tropical disease that disproportionately affects the poor. Antivenom is the only specific and effective treatment for snakebite, but its distribution is severely limited by several factors, including the prohibitive cost of some products. Papua New Guinea (PNG) is a snakebite hotspot but the high costs of Australian antivenoms (thousands of dollars per treatment) makes it unaffordable in PNG. A more economical taipan antivenom has recently been developed at the Instituto Clodomiro Picado (ICP) in Costa Rica for PNG and is currently undergoing clinical trials for the treatment of envenomations by coastal taipans (Oxyuranus scutellatus). In addition to potentially havi..

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Grants

Awarded by Australian Research Council


Funding Acknowledgements

CNZ, BODB, and JD were recipients of PhD scholarships administered by the University of Queensland. BGF was funded by a University of Queensland Infrastructure and Equipment grant and Australian Research Council Discovery Project DP190100304 and the UQ Science With Impact Fund. We are grateful for the comments from two anonymous reviewers who improved this manuscript.