Journal article
Effect of Sustained Inflations vs Intermittent Positive Pressure Ventilation on Bronchopulmonary Dysplasia or Death among Extremely Preterm Infants: The SAIL Randomized Clinical Trial
H Kirpalani, SJ Ratcliffe, M Keszler, PG Davis, EE Foglia, A Te Pas, M Fernando, A Chaudhary, R Localio, AH Van Kaam, W Onland, LS Owen, GM Schmölzer, A Katheria, H Hummler, G Lista, S Abbasi, D Klotz, B Simma, V Nadkarni Show all
JAMA Journal of the American Medical Association | AMER MEDICAL ASSOC | Published : 2019
Abstract
Importance: Preterm infants must establish regular respirations at delivery. Sustained inflations may establish lung volume faster than short inflations. Objective: To determine whether a ventilation strategy including sustained inflations, compared with standard intermittent positive pressure ventilation, reduces bronchopulmonary dysplasia (BPD) or death at 36 weeks' postmenstrual age without harm in extremely preterm infants. Design, Setting, and Participants: Unmasked, randomized clinical trial (August 2014 to September 2017, with follow-up to February 15, 2018) conducted in 18 neonatal intensive care units in 9 countries. Preterm infants 23 to 26 weeks' gestational age requiring resuscit..
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Awarded by National Institutes of Health
Funding Acknowledgements
The trial was funded by the NICHD (grant 1-U01-HD072906-01A1). Fisher & Paykel Healthcare (Auckland, New Zealand) donated masks for the study at some sites.