Journal article
Neuroimaging and connectomics of drug-resistant epilepsy at multiple scales: From focal lesions to macroscale networks
S Tavakol, J Royer, AJ Lowe, L Bonilha, JI Tracy, GD Jackson, JS Duncan, A Bernasconi, N Bernasconi, BC Bernhardt
Epilepsia | WILEY | Published : 2019
DOI: 10.1111/epi.14688
Abstract
Epilepsy is among the most common chronic neurologic disorders, with 30%-40% of patients having seizures despite antiepileptic drug treatment. The advent of brain imaging and network analyses has greatly improved the understanding of this condition. In particular, developments in magnetic resonance imaging (MRI) have provided measures for the noninvasive characterization and detection of lesions causing epilepsy. MRI techniques can probe structural and functional connectivity, and network analyses have shaped our understanding of whole-brain anomalies associated with focal epilepsies. This review considers the progress made by neuroimaging and connectomics in the study of drug-resistant epil..
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Awarded by Fonds de Recherche du Québec - Santé
Funding Acknowledgements
Leonardo Bonilha receives research support from the National Institutes of Health/National Institute on Deafness and Other Communication Disorders (DC014021 and DC014664) and from the American Heart Association (SFDRN26030003). Neda Bernasconi was funded by the Canadian Institutes for Health Research (CIHR) and received salary support from the Fonds de la Recherche du Quebec - Sante (FRQS). Andrea Bernasconi acknowledges funding from CIHR, National Science and Engineering Research Council of Canada (NSERC), and the Quebec BioImaging Network (QBIN). Boris Bernhardt acknowledges research support from NSERC (Discovery-1304413), CIHR (FDN-154298), Azrieli Center for Autism Research of the Montreal Neurological Institute (ACAR), SickKids Foundation (NI17-039), and salary support from FRQS (Chercheur Boursier Junior 1). We apologize to all the investigators whose research could not be appropriately cited owing to space limitations.