Journal article

Depression related cerebral pathology and its relationship with cognitive functioning: A systematic review

Alec Jamieson, Alicia M Goodwill, Mario Termine, Stephen Campbell, Cassandra Szoeke

JOURNAL OF AFFECTIVE DISORDERS | ELSEVIER | Published : 2019

Abstract

BACKGROUND: Depression's relationship with cerebral abnormalities and cognitive decline is temporally dynamic. Despite clear clinical utility, understanding depression's effect on cerebral structures, cognitive impairment and the interaction between these symptoms has had limited consideration. METHODS: This review summarised studies examining a clinical depression diagnosis or validated scales measuring depressive symptoms, data concerning amyloid-beta (Aβ) levels, brain structure and function focusing on hippocampal alterations, or white matter hyperintensities (WMH), and at least one validated neuropsychological test. Online database searches of: PsycINFO, EMBASE, MEDLINE, and Scopus were..

View full abstract

Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Alzheimer's Association


Funding Acknowledgements

Funding for the Healthy Ageing Program (HAP) has been provided by the National Health and Medical Research Council (NHMRC Grants 547600, 1032350 & 1062133), Ramaciotti Foundation, Australian Healthy Ageing Organisation, the Brain Foundation, the Alzheimer's Association (NIA320312), Australian Menopausal Society, Bayer Healthcare, Shepherd Foundation, Scobie and Claire Mackinnon Foundation, Collier Trust Fund, J.O. & J.R. Wicking Trust, Mason Foundation and the Alzheimer's Association of Australia. Inaugural funding was provided by VicHealth and the NHMRC. The Principal Investigator of HAP (Cassandra Szoeke) is supported by the National Health and Medical Research Council (NHMRC Grants 547600, 1032350 and 1062133.