Anesthetic technique and cancer outcomes: a meta-analysis of total intravenous versus volatile anesthesia
Andrea Yap, Maria A Lopez-Olivo, Julia Dubowitz, Jonathan Hiller, Bernhard Riedel, Timothy Wigmore, Marissa Ferguson, David Shan, Ken Yee, Ilonka Meyer, Robert Schier, Vijaya Gottumukkala, Jonathan Wilks, Volker Schick, Victor Hui, Erica Sloan, Juan Cata, Donal Buggy
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE | SPRINGER | Published : 2019
PURPOSE: Cancer-related mortality, a leading cause of death worldwide, is often the result of metastatic disease recurrence. Anesthetic techniques have varying effects on innate and cellular immunity, activation of adrenergic-inflammatory pathways, and activation of cancer-promoting cellular signaling pathways; these effects may translate into an influence of anesthetic technique on long-term cancer outcomes. To further analyze the effects of propofol (intravenous) and volatile (inhalational gas) anesthesia on cancer recurrence and survival, we undertook a systematic review with meta-analysis. SOURCE: Databases were searched up to 14 November 2018. Comparative studies examining the effect of..View full abstract
Awarded by Australian and New Zealand College of Anaesthetists Foundation
This work is funded by the Australian and New Zealand College of Anaesthetists Foundation (18/038). Dr. Lopez-Olivo's work is supported by the Rheumatology Research Foundation. Dr. Dubowitz's work is funded by Monash University PhD and ANZCA scholarships. The authors would like to thank Greg Pratt (The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA) for support with the literature searches.