Journal article

Septal GABA and Glutamate Neurons Express RXFP3 mRNA and Depletion of Septal RXFP3 Impaired Spatial Search Strategy and Long-Term Reference Memory in Adult Mice

Mouna Haidar, Kimberly Tin, Cary Zhang, Mohsen Nategh, Joao Covita, Alexander D Wykes, Jake Rogers, Andrew L Gundlach



Relaxin-3 is a highly conserved neuropeptide abundantly expressed in neurons of the nucleus incertus (NI), which project to nodes of the septohippocampal system (SHS) including the medial septum/diagonal band of Broca (MS/DB) and dorsal hippocampus, as well as to limbic circuits. High densities of the Gi=o-proteincoupled receptor for relaxin-3, known as relaxin-family peptide-3 receptor (RXFP3) are expressed throughout the SHS, further suggesting a role for relaxin-3/RXFP3 signaling in modulating learning and memory processes that occur within these networks. Therefore, this study sought to gain further anatomical and functional insights into relaxin- 3/RXFP3 signaling in the mouse MS/DB. Us..

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University of Melbourne Researchers


Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This work was funded by National Health and Medical Research Council of Australia, Grant number: 1024885 (AG) and 1067522 (AG); Brain and Behavior Research Foundation (USA) NARSAD Independent Investigator Award (AG); International Brain Research Organisation/International Society for Neurochemistry Research Fellowship (MN); Victorian Government Operational Infrastructure Support Programme (The Florey); Alzheimer's Australia Dementia Research Foundation, Postgraduate Scholarship (MH, AW); Bethlehem Griffiths Research Foundation, Postgraduate Scholarship (CZ) and Melbourne International Research Scholarship (JC, JR).