Septal GABA and Glutamate Neurons Express RXFP3 mRNA and Depletion of Septal RXFP3 Impaired Spatial Search Strategy and Long-Term Reference Memory in Adult Mice

Mouna Haidar; Kimberly Tin; Cary Zhang; Mohsen Nategh; Joao Covita; Alexander D Wykes; Jake Rogers; Andrew L Gundlach

Journal article

Septal GABA and Glutamate Neurons Express RXFP3 mRNA and Depletion of Septal RXFP3 Impaired Spatial Search Strategy and Long-Term Reference Memory in Adult Mice

Mouna Haidar, Kimberly Tin, Cary Zhang, Mohsen Nategh, Joao Covita, Alexander D Wykes, Jake Rogers, Andrew L Gundlach

FRONTIERS IN NEUROANATOMY | FRONTIERS MEDIA SA | Published : 2019

DOI: 10.3389/fnana.2019.00030

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Abstract

Relaxin-3 is a highly conserved neuropeptide abundantly expressed in neurons of the nucleus incertus (NI), which project to nodes of the septohippocampal system (SHS) including the medial septum/diagonal band of Broca (MS/DB) and dorsal hippocampus, as well as to limbic circuits. High densities of the Gi=o-proteincoupled receptor for relaxin-3, known as relaxin-family peptide-3 receptor (RXFP3) are expressed throughout the SHS, further suggesting a role for relaxin-3/RXFP3 signaling in modulating learning and memory processes that occur within these networks. Therefore, this study sought to gain further anatomical and functional insights into relaxin- 3/RXFP3 signaling in the mouse MS/DB. Us..

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Mouna Haidar Author

Andrew Gundlach Author

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Grants

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This work was funded by National Health and Medical Research Council of Australia, Grant number: 1024885 (AG) and 1067522 (AG); Brain and Behavior Research Foundation (USA) NARSAD Independent Investigator Award (AG); International Brain Research Organisation/International Society for Neurochemistry Research Fellowship (MN); Victorian Government Operational Infrastructure Support Programme (The Florey); Alzheimer's Australia Dementia Research Foundation, Postgraduate Scholarship (MH, AW); Bethlehem Griffiths Research Foundation, Postgraduate Scholarship (CZ) and Melbourne International Research Scholarship (JC, JR).