The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease

Nicolai Franzmeier; Jinyi Ren; Alexander Damm; Gemma Monte-Rubio; Merce Boada; Agustin Ruiz; Alfredo Ramirez; Frank Jessen; Emrah Duezel; Octavio Rodriguez Gomez; Tammie Benzinger; Alison Goate; Celeste M Karch; Anne M Fagan; Eric McDade; Katharina Buerger; Johannes Levin; Marco Duering; Martin Dichgans; Marc Suarez-Calvet; Christian Haass; Brian A Gordon; Yen Ying Lim; Colin L Masters; Daniel Janowitz; Cihan Catak; Steffen Wolfsgruber; Michael Wagner; Esther Milz; Sonia Moreno-Grau; Stefan Teipel; Michel J Grothe; Ingo Kilimann; Martin Rossor; Nick Fox; Christoph Laske; Jasmeer Chhatwal; Peter Falkai; Robert Perneczky; Jae-Hong Lee; Annika Spottke; Henning Boecker; Frederic Brosseron; Klaus Fliessbach; Michael T Heneka; Peter Nestor; Oliver Peters; Manuel Fuentes; Felix Menne; Josef Priller; Eike J Spruth; Christiana Franke; Anja Schneider; Christine Westerteicher; Oliver Speck; Jens Wiltfang; Claudia Bartels; Miguel angel Araque Caballero; Coraline Metzger; Daniel Bittner; Stephen Salloway; Adrian Danek; Jason Hassenstab; Igor Yakushev; Peter R Schofield; John C Morris; Randall J Bateman; Michael Ewers

Journal article

The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease

Nicolai Franzmeier, Jinyi Ren, Alexander Damm, Gemma Monte-Rubio, Merce Boada, Agustin Ruiz, Alfredo Ramirez, Frank Jessen, Emrah Duezel, Octavio Rodriguez Gomez, Tammie Benzinger, Alison Goate, Celeste M Karch, Anne M Fagan, Eric McDade, Katharina Buerger, Johannes Levin, Marco Duering, Martin Dichgans, Marc Suarez-Calvet Show all

MOLECULAR PSYCHIATRY | SPRINGERNATURE | Published : 2021

DOI: 10.1038/s41380-019-0404-6

Abstract

In Alzheimer's disease (AD), a single-nucleotide polymorphism in the gene encoding brain-derived neurotrophic factor (BDNFVal66Met) is associated with worse impact of primary AD pathology (beta-amyloid, Aβ) on neurodegeneration and cognitive decline, rendering BDNFVal66Met an important modulating factor of cognitive impairment in AD. However, the effect of BDNFVal66Met on functional networks that may underlie cognitive impairment in AD is poorly understood. Using a cross-validation approach, we first explored in subjects with autosomal dominant AD (ADAD) from the Dominantly Inherited Alzheimer Network (DIAN) the effect of BDNFVal66Met on resting-state fMRI assessed functional networks. In se..

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