Attenuated infectious laryngotracheitis virus vaccines differ in their capacity to establish latency in the trigeminal ganglia of specific pathogen free chickens following eye drop inoculation

Dulari S Thilakarathne; Mauricio JC Coppo; Carol A Hartley; Andres Diaz-Mendez; Jose A Quinteros; Omid Fakhri; Paola K Vaz; Joanne M Devlin

Journal article

Attenuated infectious laryngotracheitis virus vaccines differ in their capacity to establish latency in the trigeminal ganglia of specific pathogen free chickens following eye drop inoculation

Dulari S Thilakarathne, Mauricio JC Coppo, Carol A Hartley, Andres Diaz-Mendez, Jose A Quinteros, Omid Fakhri, Paola K Vaz, Joanne M Devlin

PLoS One | Public Library of Science (PLoS) | Published : 2019

DOI: 10.1371/journal.pone.0213866

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Abstract

Infectious laryngotracheitis (ILT) is a respiratory disease that affects chickens. It is caused by the alphaherpesvirus, infectious laryngotracheitis virus (ILTV). This virus undergoes lytic replication in the epithelial cells of the trachea and upper respiratory tract (URT) and establishes latent infection in the trigeminal ganglia (TG) and trachea. Live attenuated vaccines are widely used to control ILT. At least one of these vaccines can establish latent infections in chickens, but this has not been demonstrated for all vaccines. The aim of the current study was to determine the capacity of three commercially available vaccines (SA2, A20 and Serva) and a glycoprotein G deletion mutant vac..

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University of Melbourne Researchers

Mauricio Coppo Author

Carol Hartley Author

Andrés Diaz-Méndez Author

Paola Vaz Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

The work was funded by the Australian Research Council through grant DP140100480 awarded to CAH and JMD and through grant FT140101287 awarded to JMD. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.