Journal article

Antiviral Candidates for Treating Hepatitis E Virus Infection

Natalie E Netzler, Daniel Enosi Tuipulotu, Subhash G Vasudevan, Jason M Mackenzie, Peter A White

Antimicrobial Agents and Chemotherapy | AMER SOC MICROBIOLOGY | Published : 2019

University of Melbourne Researchers


Awarded by National Health and Medical Research Council

Funding Acknowledgements

We thank Suzanne Emerson (National Institute of Allergy and Infectious Diseases, NIH) and X. J. Meng (Virginia-Maryland College of Veterinary Medicine) for generously providing the plasmid to generate the G1 HEV replicon used in this study. We also thank Mark Douglas (Westmead Institute for Medical Research, Sydney, Australia) for providing the Huh7 cell line used in this study. We thank Kitti Wing-Ki Chan (Emerging Infectious Diseases Program, Duke-NUS Medical School, Singapore) for her assistance during our collaboration. Finally, we thank Gerhard Purstinger (formerly of Institute of Pharmacy, University of Innsbruck, Austria) for providing the compound GPC-N114. This work was funded by the National Health and Medical Research Council, grant/award numbers APP1083139 and APP1123135. N.E.N. and P.A.W. conceived the study, D.E.T. assisted N.E.N. with experimental design, and N.E.N. designed and performed the experiments under the supervision of P.A.W. S.G.V. and J.M.M. provided expertise and materials. N.E.N. and P.A.W. analyzed and interpreted the data. N.E.N. wrote the manuscript with the help of P.A.W., and it was edited by D.E.T., S.G.V., and J.M.M. We have no conflicts of interest to declare and nothing to disclose.