Umbilical cord blood versus mesenchymal stem cells for inflammation-induced preterm brain injury in fetal sheep
Madison CB Paton, Beth J Allison, Michael C Fahey, Jingang Li, Amy E Sutherland, Yen Pham, Ilias Nitsos, Robert J Bischof, Timothy J Moss, Graeme R Polglase, Graham Jenkin, Suzanne L Miller, Courtney A McDonald
Pediatric Research | NATURE PUBLISHING GROUP | Published : 2019
BACKGROUND: Chorioamnionitis and fetal inflammation are principal causes of neuropathology detected after birth, particularly in very preterm infants. Preclinical studies show that umbilical cord blood (UCB) cells are neuroprotective, but it is uncertain if allogeneic UCB cells are a feasible early intervention for preterm infants. In contrast, mesenchymal stem cells (MSCs) are more readily accessible and show strong anti-inflammatory benefits. We aimed to compare the neuroprotective benefits of UCB versus MSCs in a large animal model of inflammation-induced preterm brain injury. We hypothesized that MSCs would afford greater neuroprotection. METHODS: Chronically instrumented fetal sheep at ..View full abstract
We would like to thank Jamie Mihelakis, Dalibor Stanojkovic, and Arielle Kogan for their technical assistance. This project was made possible with financial support from the Cerebral Palsy Alliance, Inner Wheel Australia, and the National Health and Medical Research Council, as well as an Australian Research Council Future Fellowship to S.L.M., NHMRC and Cerebral Palsy Alliance Early Career Research Fellowship to C.A.M. and Kahli Sargent Research Studentship and Australian Government Research Training Program Scholarship to M.C.B.P. All included authors met the Pediatric Research authorship requirements.