Journal article

The Contribution of Multiparametric Pelvic and Whole-Body MRI to Interpretation of F-18-Fluoromethylcholine or Ga-68-HBED-CC PSMA-11 PET/CT in Patients with Biochemical Failure After Radical Prostatectomy

Ur Metser, Sue Chua, Bao Ho, Shonit Punwani, Edward Johnston, Frederic Pouliot, Noam Tau, Asmaa Hawsawy, Reut Anconina, Glenn Bauman, Rodney J Hicks, Andrew Weickhardt, Ian D Davis, Greg Pond, AndrewM Scott, Nina Tunariu, Harbir Sidhu, Louise Emmett

Journal of Nuclear Medicine | SOC NUCLEAR MEDICINE INC | Published : 2019

Abstract

Purpose: To assess whether the addition of data from multiparametric pelvic (mpMR) and whole body MR (wbMR) to the interpretation of 18F-fluoromethylcholine (FCH) or 68Ga-HBED-CC PSMA-11 (PSMA) PET/CT (=PET) improves the detection of local tumor recurrence, or nodal and distant metastases in patients following radical prostatectomy with biochemical failure. Methods: The current analysis was performed as part of a prospective, multicenter trial on FCH / PSMA PET, mpMR and wbMR. Eligible men had elevated PSA (>0.2 ng/ml) and high-risk features (Gleason score >7, PSA doubling time 1.0 ng/ml) with negative/ equivocal conventional imaging. PET was interpreted with mp&wbMR in consensus by 2 radiol..

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