Journal article
The contribution of multiparametric pelvic and whole-body MRI to interpretation of 18F-fluoromethylcholine or 68Ga-HBED-CC PSMA-11 PET/CT in patients with biochemical failure after radical prostatectomy
U Metser, S Chua, B Ho, S Punwani, E Johnston, F Pouliot, N Tau, A Hawsawy, R Anconina, G Bauman, RJ Hicks, A Weickhardt, ID Davis, G Pond, AM Scott, N Tunariu, H Sidhu, L Emmett
Journal of Nuclear Medicine | SOC NUCLEAR MEDICINE INC | Published : 2019
Abstract
Our purpose was to assess whether the addition of data from multiparametric pelvic MRI (mpMR) and whole-body MRI (wbMR) to the interpretation of 18F-fluoromethylcholine (18F-FCH) or 68Ga-HBED-CC PSMA-11 (68Ga-PSMA) PET/CT (5PET) improves the detection of local tumor recurrence or of nodal and distant metastases in patients after radical prostatectomy with biochemical failure. Methods: The current analysis was performed as part of a prospective, multicenter trial on 18F-FCH or 68Ga-PSMA PET, mpMR, and wbMR. Eligible men had an elevated level of prostate-specific antigen (PSA) (.0.2 ng/mL) and high-risk features (Gleason score . 7, PSA doubling time, 10 mo, or PSA . 1.0 ng/mL) with negative or..
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Awarded by Movember Foundation
Funding Acknowledgements
We acknowledge the invaluable guidance and tireless support of Sam Gledhill of the Movember Foundation. Further thanks are given to the Society of Nuclear Medicine and Molecular Imaging team headed by Bonnie Clark for their role in the management of the imaging and data collection. We also acknowledge the support of local clinical trials teams in bringing together this project.