Journal article

A genome-wide analysis of carbon catabolite repression in Schizosaccharomyces pombe

Dane Vassiliadis, Koon Ho Wong, Alex Andrianopoulos, Brendon J Monahan

BMC GENOMICS | BMC | Published : 2019


BACKGROUND: Optimal glucose metabolism is central to the growth and development of cells. In microbial eukaryotes, carbon catabolite repression (CCR) mediates the preferential utilization of glucose, primarily by repressing alternate carbon source utilization. In fission yeast, CCR is mediated by transcriptional repressors Scr1 and the Tup/Ssn6 complex, with the Rst2 transcription factor important for activation of gluconeogenesis and sexual differentiation genes upon derepression. Through genetic and genome-wide methods, this study aimed to comprehensively characterize CCR in fission yeast by identifying the genes and biological processes that are regulated by Scr1, Tup/Ssn6 and Rst2, the c..

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