A genome-wide analysis of carbon catabolite repression in Schizosaccharomyces pombe
Dane Vassiliadis, Koon Ho Wong, Alex Andrianopoulos, Brendon J Monahan
BMC GENOMICS | BMC | Published : 2019
BACKGROUND: Optimal glucose metabolism is central to the growth and development of cells. In microbial eukaryotes, carbon catabolite repression (CCR) mediates the preferential utilization of glucose, primarily by repressing alternate carbon source utilization. In fission yeast, CCR is mediated by transcriptional repressors Scr1 and the Tup/Ssn6 complex, with the Rst2 transcription factor important for activation of gluconeogenesis and sexual differentiation genes upon derepression. Through genetic and genome-wide methods, this study aimed to comprehensively characterize CCR in fission yeast by identifying the genes and biological processes that are regulated by Scr1, Tup/Ssn6 and Rst2, the c..View full abstract
Awarded by Research and Development Administration Office of the University of Macau
This work was supported by funding from the Research and Development Administration Office of the University of Macau to Koon Ho Wong (grant number: MYRG2016-00211-FHS). The funding body had no role in the design of the study, collection, analysis or interpretation of data or in writing of the manuscript.