Journal article

Clinical trials of antiretroviral treatment interruption in HIV-infected individuals

Jillian SY Lau, Miranda Z Smith, Sharon R Lewin, James H McMahon

AIDS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019

Abstract

: Despite the benefits of antiretroviral therapy (ART) for people living with HIV, there has been a long-standing research interest in interrupting ART as a strategy to minimize adverse effects of ART as well as to test interventions aiming to achieve a degree of virological control without ART. We performed a systematic review of HIV clinical studies involving treatment interruption from 2000 to 2017 to describe the differences between treatment interruption in studies that contained and didn't contain an intervention. We assessed differences in monitoring strategies, threshold to restart ART, duration and adverse outcomes of treatment interruption, and factors aimed at minimizing transmiss..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) Postgraduate Scholarship


Awarded by NHMRC Early Career Fellowship


Awarded by NHMRC


Awarded by National Institutes of Health Delaney AIDS Research Enterprise


Awarded by American Foundation for AIDS Research


Funding Acknowledgements

J.S.Y.L. holds a National Health and Medical Research Council (NHMRC) Postgraduate Scholarship (1151607). J.H.M. holds an NHMRC Early Career Fellowship (1111099). S.R.L. is an NHMRC Practitioner Fellow (1042654) and is supported by the National Institutes of Health Delaney AIDS Research Enterprise (UM1 AI126611-01) and the American Foundation for AIDS Research (109226-58 RGRL). S.R.L. has participated in advisory roles and educational activities of Viiv and Merck Sharp & Dohme Corp. All honoraria were paid to the investigator's institutions.