Journal article

Genome organization in immune cells: unique challenges

Timothy M Johanson, Wing Fuk Chan, Christine R Keenan, Rhys S Allan

NATURE REVIEWS IMMUNOLOGY | NATURE PUBLISHING GROUP | Published : 2019

Abstract

Each type of cell in the immune system performs critical functions to protect the body and maintain health. In order to fulfil these roles some immune cells rely on unique processes, including antigen receptor loci recombination, clonal expansion or the contortion of their nuclei. In turn, each of these processes relies on, or poses unique challenges to, a genome organized in three dimensions. Here, we explore the current understanding of the importance of 3D genome organization in the function and development of a healthy immune system.

Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by Australian Research Council


Funding Acknowledgements

The authors thank S. Nutt, A. Johanson, N. Alpern and H. Batterham for constructive discussion. This work was supported by grants and fellowships from the National Health and Medical Research Council (NHMRC) of Australia (R.S.A.: #1049307 and #1100451; T.M.J.: #1124081; and C.R.K.: #1125436) and the Australian Research Council (R.S.A.: #130100541). This study was made possible through the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institute Infrastructure Support scheme.