Journal article

Measurement of liver fat by MRI and its reduction by dexfenfluramine in NIDDM

SJ Marks, NR Moore, NG Ryley, ML Clark, JJ Pointon, BJG Strauss, TDR Hockaday

INTERNATIONAL JOURNAL OF OBESITY | STOCKTON PRESS | Published : 1997

Abstract

OBJECTIVE: To validate a variation of a well-established magnetic resonance imaging (MRI) technique to detect liver fat and use it to monitor liver fat changes after treatment with dexfenfluramine in men with non-insulin dependent diabetes mellitus (NIDDM). DESIGN: (a) Simple correlation study of MRI Liver Fat Index with liver biopsy results; (b) Open Study of 10 men with NIDDM treated with dexfenfluramine for 12 weeks in addition to their 'usual' therapy. SUBJECTS: (a) 19 patients (3F; 16M) with abnormal liver function tests undergoing liver biopsy; (b) 10 men, Body Mass Index (BMI) 0.90 with poorly controlled NIDDM despite oral sulphonylurea therapy. MEASUREMENTS: (a) MRI liver fat; stand..

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University of Melbourne Researchers