Journal article

Effect of adolescent androgen manipulation on psychosis-like behaviour in adulthood in BDNF heterozygous and control mice

X Du, CR McCarthny, M Notaras, M van den Buuse, RA Hill

HORMONES AND BEHAVIOR | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2019

Abstract

RATIONALE: Males are more prone to psychosis, schizophrenia and substance abuse and addiction in adolescence and early adulthood than females. However, the role of androgens during this developmental period is poorly understood. OBJECTIVES: This study aimed to examine how androgens in adolescence influence psychosis-like behaviour in adulthood and whether brain-derived neurotrophic factor (BDNF) is a mediator of these developmental effects. METHODS: Wild-type and BDNF heterozygous male mice were castrated at pre-pubescence and implanted with testosterone or dihydrotestosterone (DHT). In adulthood, we assessed amphetamine- and MK-801-induced hyperlocomotion as a model of psychosis-like behavi..

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Grants

Awarded by NHMRC project grant


Awarded by Brain and Behavior Research Foundation (USA) NARSAD Young Investigator Award


Funding Acknowledgements

This work was supported by a NHMRC project grant (grant#1044887); XD performed all surgical and behavioural testing as well as molecular analyses and is supported by a NHMRC-ARC Dementia Research Development Fellowship; CRM and MN both assisted in the molecular analyses; MN was supported by an APA scholarship awarded by the University of Melbourne. MvdB was supported by a NHMRC Senior Research Fellowship; RH was supported by a Brain and Behavior Research Foundation (USA) NARSAD Young Investigator Award (grant #22997) and a NHMRC Career Development Fellowship.