Conference Proceedings
UBIQUITINATED PROTEINS ARE ELEVATED IN THE BLOOD AND BRAIN OF INDIVIDUALS WITH SCHIZOPHRENIA
Chad Bousman, Sandra Luza, Serafino Mancuso, Dali Kang, Md Shaki Mostaid, Vanessa Cropley, Cynthia Shannon Weickert, Carlos Opazo, Christos Pantelis, Ashley Bush, Ian Paul Everall
EUROPEAN NEUROPSYCHOPHARMACOLOGY | ELSEVIER SCIENCE BV | Published : 2019
Abstract
Background Evidence from genome-wide association, microarray, and protein studies have indicated dysregulation of genes and proteins within the Ubiquitin Proteasome Pathway (UPP) in the blood and brain of individuals with schizophrenia. However, it is not clear which components of the UPP, if any, are dysregulated in both blood and brain. Methods We obtained frozen postmortem Orbitofrontal Cortex (OFC) tissue from 76 (38 schizophrenia, 38 control) individuals and erythrocytes from 181 participants, comprising 30 individuals with recent onset schizophrenia (mean illness duration=1 year), 63 individuals with schizophrenia treated with clozapine and considered ‘treatment-resistant’ (mean illnes..
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