Gallbladder Dyskinesia Is Associated With an Impaired Postprandial Fibroblast Growth Factor 19 Response in Critically Ill Patients
Kiran VK Koelfat, Mark P Plummer, Frank G Schaap, Martin Lenicek, Peter LM Jansen, Adam M Deane, Steven WM Olde Damink
HEPATOLOGY | WILEY | Published : 2019
Critical illness is associated with a disturbed regulation of gastrointestinal hormones resulting in functional and metabolic anomalies. Fibroblast growth factor 19 (FGF19) is an ileum-derived metabolic hormone induced by bile salts upon gallbladder emptying after enteral nutrient stimulation. Our aim was to study the nutrient-stimulated FGF19 response in 24 patients admitted to the intensive care unit (ICU) compared with 12 healthy controls. All subjects received intraduodenal high-lipid nutrient infusion for 120 minutes. Blood was collected every 30 minutes until 1 hour after infusion, and gallbladder emptying was studied by ultrasound. Serum levels of bile salts and FGF19 were assessed. I..View full abstract
Awarded by Netherlands Organization for Scientific Research
Supported by a grant (to K.V.K.K.) from the Netherlands Organization for Scientific Research (NWO 022.003.011).