Unraveling the role of the MOV10 RNA helicase during influenza A virus infection

Fernando Villalon-Letelier; Patrick C Reading

Journal article

Unraveling the role of the MOV10 RNA helicase during influenza A virus infection

Fernando Villalon-Letelier, Patrick C Reading

BIOCHEMICAL JOURNAL | PORTLAND PRESS LTD | Published : 2019

DOI: 10.1042/BCJ20190018

Abstract

Moloney leukemia virus 10 (MOV10) is an interferon-inducible RNA helicase that has been implicated in a broad range of cellular functions, including modulating the replication of a diverse range of viruses. However, the mechanisms by which MOV10 promotes or inhibits the replication of particular viruses have not been well defined. A recent paper published in the Biochemical Journal by Li et al. [Biochem. J. (2019) 476, 467-481] provides insight regarding the mechanisms by which MOV10 restricts influenza A virus (IAV) infection in host cells. First, the authors confirm that MOV10 binds to the viral nucleoprotein (NP) and sequesters the viral ribonucleoprotein complex in cytoplasmic granules c..

View full abstract

University of Melbourne Researchers

Patrick Reading Author Microbiology and Immunology

Related Projects (1)

IDENTIFICATION OF HOST RESTRICTION FACTORS THAT BLOCK RESPIRATORY VIRUS INFECTION

Following inhalation, respiratory viruses can infect and grow in airway epithelial cells. Although immune cells such as macrophages are also..

Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Funding Acknowledgements

This work was supported by Project Grant APP1143154 from the National Health and Medical Research Council (NHMRC) of Australia. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health.