Unraveling the role of the MOV10 RNA helicase during influenza A virus infection
Fernando Villalon-Letelier, Patrick C Reading
BIOCHEMICAL JOURNAL | PORTLAND PRESS LTD | Published : 2019
Moloney leukemia virus 10 (MOV10) is an interferon-inducible RNA helicase that has been implicated in a broad range of cellular functions, including modulating the replication of a diverse range of viruses. However, the mechanisms by which MOV10 promotes or inhibits the replication of particular viruses have not been well defined. A recent paper published in the Biochemical Journal by Li et al. [Biochem. J. (2019) 476, 467-481] provides insight regarding the mechanisms by which MOV10 restricts influenza A virus (IAV) infection in host cells. First, the authors confirm that MOV10 binds to the viral nucleoprotein (NP) and sequesters the viral ribonucleoprotein complex in cytoplasmic granules c..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
This work was supported by Project Grant APP1143154 from the National Health and Medical Research Council (NHMRC) of Australia. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health.