Journal article

Characterization of the relaxin family peptide receptor 3 system in the mouse bed nucleus of the stria terminalis

Sarah S Ch'ng, Jingjing Fu, Robyn M Brown, Craig M Smith, Mohammed Akhter Hossain, Stuart J McDougall, Andrew J Lawrence

Journal of Comparative Neurology | WILEY | Published : 2019


The bed nucleus of the stria terminalis (BNST) is a critical node involved in stress and reward-related behaviors. Relaxin family peptide receptor 3 (RXFP3) signaling in the BNST has been implicated in stress-induced alcohol seeking behavior. However, the neurochemical phenotype and connectivity of BNST RXFP3-expressing (RXFP3+) cells have yet to be elucidated. We interrogated the molecular signature and electrophysiological properties of BNST RXFP3+ neurons using a RXFP3-Cre reporter mouse line. BNST RXFP3+ cells are circumscribed to the dorsal BNST (dBNST) and are neurochemically heterogeneous, comprising a mix of inhibitory and excitatory neurons. Immunohistochemistry revealed that ~48% o..

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