Journal article

An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity

Nirmin Alsahafi, Nordine Bakouche, Mohsen Kazemi, Jonathan Richard, Shilei Ding, Sudipta Bhattacharyya, Durba Das, Sai Priya Anand, Jeremie Prevost, William D Tolbert, Hong Lu, Halima Medjahed, Gabrielle Gendron-Lepage, Gloria Gabrielle Ortega Delgado, Sharon Kirk, Bruno Melillo, Walther Mothes, Joseph Sodroski, Amos B Smith, Daniel E Kaufmann Show all

Cell Host & Microbe | CELL PRESS | Published : 2019

Grants

Awarded by CIHR foundation


Awarded by NIH R01


Awarded by NIAID R01


Awarded by Canada Research Chair on Retroviral Entry


Awarded by National Cancer Institute, NIH


Awarded by NIH


Awarded by NIH Center for HIV/AIDS Vaccine Immunology and Immunogen Design (CHAVI-ID)



Funding Acknowledgements

The authors thank Maolin Lu and Xiaochu Ma for helpful discussions and critical reading of the manuscript, the CRCHUM Flow Cytometry Platform, the FRQS AIDS and Infectious Diseases network, Mario Legault for cohort coordination and clinical samples, and Dennis Burton for the infectious molecular clone JRFL. We would like to thank Andrew Leis from the Bio21 Advanced Microscopy Facility (University of Melbourne). This work was supported by a CIHR foundation grant #352417 to A. F. Support for this work was also provided by NIH R01 to A. F. and M. P. (AI129769), A. F. and X. W. (AI122953), J. S. (AI124982), and NIAID R01 to M. P. (AI116274). This study was also supported by NIH AI100663 Center for HIV/AIDS Vaccine Immunology and Immunogen Design (CHAVI-ID) (D. E. K.; PI: Dennis Burton) and by R01-GM56550 to A.B.S. Work by J.B.M. was supported by the NIH (1K22AI116262), the Gilead Sciences Research Scholars Program in HIV, and the Campbell Foundation for AIDS Research. A.F. is the recipient of a Canada Research Chair on Retroviral Entry #RCHS0235. N.A. is the recipient of a King Abdullah scholarship for higher education from the Saudi Government. J.R. is the recipient of a Mathilde Krim Fellowships in Basic Biomedical Research from AmfAR. S.D. is the recipient of an FRSQ postdoctoral fellowship award. D.E.K. is supported by an FRQS Senior Research Scholar Award. I.R. is supported by the STEM-M Stimulus Fund (University of Melbourne). We thank Jeffrey Lifson and Julian Bess for providing the AT-2 inactivated viral particles from the AIDS and Cancer Virus Program, and Leidos Biomedical Research, Inc./Frederick National Laboratory for Cancer Research supported with federal funds from the National Cancer Institute, NIH, under contract HHSN261200800001E. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The views expressed in this presentation are those of the authors and do not reflect the official policy or position of the Uniformed Services University, US Army, the Department of Defense, or the US Government.