Journal article

Circulating Tumor DNA Analysis and Functional Imaging Provide Complementary Approaches for Comprehensive Disease Monitoring in Metastatic Melanoma

Stephen Q Wong, Jeanette M Raleigh, Jason Callahan, Ismael A Vergara, Sarah Ftouni, Athena Hatzimihalis, Andrew J Colebatch, Jason Li, Timothy Semple, Kenneth Doig, Christopher Mintoff, Devbarna Sinha, Paul Yeh, Maria Joao Silva, Kathryn Alsop, Heather Thorne, David D Bowtell, David E Gyorki, Gisela Mir Arnau, Carleen Cullinane Show all



Purpose Circulating tumorDNA(ctDNA) allows noninvasive disease monitoring across a range of malignancies. In metastatic melanoma, the extent to which ctDNA reflects changes in metabolic disease burden assessed by 18F-labeled fluorodeoxyglucose positron emission tomography (FDG-PET) is unknown.Weassessed the role ofctDNAanalysis in combination with FDG-PET to monitor tumor burden and genomic heterogeneity throughout treatment. PatientsandMethodsWeperformed a comprehensiveanalysis of serialctDNAandFDG-PETin 52 patients who received systemic therapy for metastatic melanoma. Next-generation sequencing and digital polymerase chain reaction were used to analyze plasma samples from the cohort. Resu..

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

Supported by a Peter MacCallum Cancer Foundation grant, the National Health and Medical Research Council (program grant APP1053792, project grant APP1107126), a Pfizer study grant, a Gundry Perpetual Endowment for melanoma research, and a Viertel Charitable Foundation Clinical Investigator Award. S.-J.D. was supported by a National Breast Cancer Foundation and Victorian Cancer Agency Fellowship. The Cancer Tissue Collection After Death (CASCADE) program was supported by the Peter MacCallum Cancer Foundation