Journal article
Extensive ethnic variation and linkage disequilibrium at the FCGR2/3 locus: Different genetic associations revealed in Kawasaki disease
SQ Nagelkerke, CE Tacke, WB Breunis, MWT Tanck, J Geissler, E Png, LT Hoang, J Van Der Heijden, ANM Naim, RSM Yeung, ML Levin, VJ Wright, DP Burgner, AL Ponsonby, JA Ellis, R Cimaz, C Shimizu, JC Burns, K Fijnvandraat, C Ellen Van Der Schoot Show all
Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2019
Abstract
The human Fc-gamma receptors (FcγRs) link adaptive and innate immunity by binding immunoglobulin G (IgG). All human low-affinity FcγRs are encoded by the FCGR2/3 locus containing functional single nucleotide polymorphisms (SNPs) and gene copy number variants. This locus is notoriously difficult to genotype and high-throughput methods commonly used focus on only a few SNPs. We performed multiplex ligation-dependent probe amplification for all relevant genetic variations at the FCGR2/3 locus in >4,000 individuals to define linkage disequilibrium (LD) and allele frequencies in different populations. Strong LD and extensive ethnic variation in allele frequencies was found across the locus. LD wa..
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Awarded by Koninklijke Nederlandse Akademie van Wetenschappen
Funding Acknowledgements
We thank Prof. Dirk Roos and Prof. Raoul Hennekam for critical reading of the manuscript, Dr. C. C. Khor, Dr. Joep Sins, Mrs. Aicha Ait Soussan, and Dr. Lonneke Haer-Wigman for help in sample collection, and the GERMS platform at Genome Institute Singapore for technical support. This work was supported by a grant from the Landsteiner Foundation for Bloodtransfusion Research (LSBR 0916) awarded to TK. CT has received a grant from the Ter Meulen Fund, Royal Netherlands Academy of Arts and Sciences (TMF2012/227). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.