Journal article

Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity

Anna C Simcocks, Kayte A Jenkin, Lannie O'Keefe, Chrishan S Samuel, Michael L Mathai, Andrew J McAinch, Deanne H Hryciw

ENDOCRINE CONNECTIONS | BIOSCIENTIFICA LTD | Published : 2019

Abstract

Atypical cannabinoid compounds O-1602 and O-1918 are ligands for the putative cannabinoid receptors G protein-coupled receptor 55 and G protein-coupled receptor 18. The role of O-1602 and O-1918 in attenuating obesity and obesity-related pathologies is unknown. Therefore, we aimed to determine the role that either compound had on body weight and body composition, renal and hepatic function in diet-induced obesity. Male Sprague-Dawley rats were fed a high-fat diet (40% digestible energy from lipids) or a standard chow diet for 10 weeks. In a separate cohort, male Sprague-Dawley rats were fed a high-fat diet for 9 weeks and then injected daily with 5 mg/kg O-1602, 1 mg/kg O-1918 or vehicle (0...

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Grants

Awarded by National Health & Medical Research Council (NHMRC) of Australia


Funding Acknowledgements

This work was supported by the Allen Foundation (D H H, A J M), and through the Australian Government's Collaborative Research Networks (CRN) program (A J M). Scholarship funding by Australian Postgraduate Award (K A J, L O) and Australian Rotary Health and the Rotary Club of Ballarat South (A C S); and Fellowship funding (C S S) by the National Health & Medical Research Council (NHMRC) of Australia [GNT1041766].