Conference Proceedings
METHYLOME-WIDE ASSOCIATION STUDIES FOR MAJOR DEPRESSIVE DISORDER IN BLOOD OVERLAP WITH METHYLATION RESULTS FROM BRAIN AND LARGE-SCALE GWAS
Karolina Aberg, Brian Dean, Andrey Shabalin, Min Zhao, Robin Chan, Mohammad Hattab, Gerard van Grootheest, Laura Han, Moji Aghajani, Yuri Milaneschi, Rick Jansen, Lin Xie, Shaunna Clark, Brenda Penninx, Edwin van den Oord
EUROPEAN NEUROPSYCHOPHARMACOLOGY | ELSEVIER SCIENCE BV | Published : 2019
Abstract
Background: Epigenetic modifications such as DNA methy- lation provide stability and diversity to the cellular phenotype and aberrant methylation has been implicated in processes underlying psychiatric disorders. Therefore, studies combining DNA methylation and genotype information provide a promis- ing approach to study disorders where genotype information alone has failed to reveal the full etiology. Methods: We applied an optimized MBD-seq protocol to assay the complete CpG methylome in cases with Major Depressive Disorder (MDD) and controls using blood samples (N=1,132) from Netherlands Study of Depression and Anxiety and brain samples (N=64) from the Victorian Brain Bank Network. Data..
View full abstract