Journal article

The FZD7-TWIST1 axis is responsible for anoikis resistance and tumorigenesis in ovarian carcinoma

Ming Tan, Mohammad Asad, Valerie Heong, Meng Kang Wong, Tuan Zea Tan, Jieru Ye, Kuee Theng Kuay, Jean Paul Thiery, Clare Scott, Ruby Yun-Ju Huang

MOLECULAR ONCOLOGY | WILEY | Published : 2019

Abstract

Frizzled family receptor 7 (FZD7), a Wnt signaling receptor, is associated with the maintenance of stem cell properties and cancer progression. FZD7 has emerged as a potential therapeutic target because it is capable of transducing both canonical and noncanonical Wnt signals. In this study, we investigated the regulatory pathway downstream of FZD7 and its functional roles. We found that FZD7 expression was crucial to the maintenance of the mesenchymal phenotype, anoikis resistance, and spheroid and tumor formation in ovarian cancer (OC). We identified TWIST1 as the crucial downstream effector of the FZD7 pathway. TWIST1, a basic helix loop helix transcription factor, is known to associate wi..

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Grants

Awarded by National Medical Research Council (NMRC) Clinician Scientist-Individual Research Grant (CS-IRG)


Awarded by National Health and Medical Research Council (NHMRC Australia)


Awarded by Victorian Cancer Agency


Funding Acknowledgements

This work is supported by the National Research Foundation Singapore and the Singapore Ministry of Education under its Research Centres of Excellence initiative to Cancer Science Institute of Singapore to JPT and RYH, National Medical Research Council (NMRC) Clinician Scientist-Individual Research Grant (CS-IRG) (NMRC/CIRG/1449/2016) to RYH, and National University Cancer Institute Singapore (NCIS) Yong Siew Yoon (YSY) Research Grant through donations from the Yong Loo Lin Trust to JPT and RYH. CS was supported by fellowships and grants from the National Health and Medical Research Council (NHMRC Australia) Project grant 1081178, the Cancer Council Victoria (Sir Edward Dunlop Fellowship in Cancer Research), and the Victorian Cancer Agency (Clinical Fellowships CRF 10-20, CRF16014).