Journal article

Adipose tissue is the first colonization site of Leptospira interrogans in subcutaneously infected hamsters

Ryo Ozuru, Mitsumasa Saito, Takaaki Kanemaru, Satoshi Miyahara, Sharon YAM Villanueva, Gerald L Murray, Ben Adler, Jun Fujii, Shin-ichi Yoshida



Leptospirosis is one of the most widespread zoonoses in the world, and its most severe form in humans, "Weil's disease," may lead to jaundice, hemorrhage, renal failure, pulmonary hemorrhage syndrome, and sometimes,fatal multiple organ failure. Although the mechanisms underlying jaundice in leptospirosis have been gradually unraveled, the pathophysiology and distribution of leptospires during the early stage of infection are not well understood. Therefore, we investigated the hamster leptospirosis model, which is the accepted animal model of human Weil's disease, by using an in vivo imaging system to observe the whole bodies of animals infected with Leptospira interrogans and to identify the..

View full abstract


Awarded by JSPS KAKENHI from the Japan Society for the Promotion of Science

Awarded by Grants-in-Aid for Scientific Research

Funding Acknowledgements

This study was supported by a grant from the Science and Technology Research Partnership for Sustainable Development (SATREPS) Program of Japan Science and Technology Agency ( and the Japan International Cooperation Agency ( to SY, and JSPS KAKENHI (Grant Number JP25460536) from the Japan Society for the Promotion of Science ( to MS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.