Journal article

Acinetobacter baumannii: Evolution of Antimicrobial Resistance-Treatment Options

Yohei Doi, Gerald L Murray, Anton Y Peleg

Seminars in Respiratory and Critical Care Medicine | THIEME MEDICAL PUBL INC | Published : 2015

Abstract

The first decade of the 20th century witnessed a surge in the incidence of infections due to several highly antimicrobial-resistant bacteria in hospitals worldwide. Acinetobacter baumannii is one such organism that turned from an occasional respiratory pathogen into a major nosocomial pathogen. An increasing number of A. baumannii genome sequences have broadened our understanding of the genetic makeup of these bacteria and highlighted the extent of horizontal transfer of DNA. Animal models of disease combined with bacterial mutagenesis have provided some valuable insights into mechanisms of A. baumannii pathogenesis. Bacterial factors known to be important for disease include outer membrane ..

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Grants

Awarded by National Institutes of Health


Awarded by Australian National Health and Medical Research Council Career Development Fellowship


Funding Acknowledgements

Y.D.'s effort was supported in part by research grants from the National Institutes of Health (R01AI104895, R21AI107302). A.Y.P would like to acknowledge support from an Australian National Health and Medical Research Council Career Development Fellowship (APP1047916).