Abstract

Abstract

Introduction: Matrix metalloproteinase (MMP) family play an important role in tissue remodelling. Expression of MMPs is increased in several types of human cancer and high levels of MMP2 in cancer cells have been associated with metastasis; however, little is known about the role of MMP2 in oral squamous cell carcinoma (OSCC). Objectives: To assess the role of MMP2 in OSCC using in vitro and in silico analyses. Materials and Methods: Two human malignant oral keratinocyte cell lines (H357/H400) were treated with ARP101, a selective chemical inhibitor of MMP2, and MA5-13590, a monoclonal antibody. Cell proliferation was assessed at 0/12/24/48 hours. Cell migration was assessed at 12/24 hours u..